Southern Belles: Louisville is set against the progressive, art-centric and warm community of Louisville, Kentucky. The show highlights southern traditions such as family values and friendship mixed with the modern lifestyles of the five women. These five contemporary and independent women are all at critical crossroads in their lives: Some are confronting their biological clocks, some are still looking for Mr. Right, some have Mr. Right and want to lock him down, and others are trying to find their career paths.

It all comes to a head when Erica suffers a series of mishaps that land her in the hospital. There she encounters the mysterious and eccentric therapist Dr. Tom who seems to know a little too much about her life. Even more bizarre, he offers to help fix her current woes -- if she accepts a challenge.

Desperate for change, Erica provides Dr. Tom with a list of her life's greatest regrets, and unexpectedly finds herself sent back in time to her teenage years. Keeping full possession of her 32-year-old mind, Erica realizes she's been given the opportunity of a lifetime - to make different choices in her past that will ultimately reshape her present.

As Erica weaves in and out of the present and past, guided of course by the mysterious Dr. Tom, she gradually realizes that she needs to take control of her destiny and stop blaming her past mistakes for her present troubles.