Sara and Brian Fitzgerald's life with their young son and their two-year-old daughter, Kate, is forever altered when they learn that Kate has leukemia. The parents' only hope is to conceive another child, specifically intended to save Kate's life. For some, such genetic engineering would raise both moral and ethical questions; for the Fitzgeralds, Sara in particular, there is no choice but to do whatever it takes to keep Kate alive. And what it takes is Anna.

Kate (Sofia Vassilieva) and Anna (Abigail Breslin) share a bond closer than most sisters: though Kate is older, she relies on her little sister--in fact, her life depends on Anna.

Throughout their young lives, the sisters endure various medical procedures and hospital stays--just another part of their close-knit family's otherwise normal life. Sara (Cameron Diaz), a loving wife and mother who left her career as an attorney to care for her daughter, is sometimes lost inside the single-minded caregiver she has become in her efforts to save Kate. Her strong, supportive husband, Brian (Jason Patric), is often rendered powerless and passive by his wife's strength and determination. And their only son, Jesse (Evan Ellingson), drifts, at times all but forgotten as Kate and Anna take center stage.

Until Anna, now 11, says "no." Seeking medical emancipation, she hires her own lawyer (Alec Baldwin), initiating a court case that divides the family and that could leave Kate's rapidly failing body in the hands of fate.

Based on the bestselling book from Jodi Picoult, "My Sister's Keeper" reveals surprising truths that challenge one's perceptions of family love and loyalty and give new meaning to the definition of healing.

Directed by Nick Cassavetes ("The Notebook"), "My Sister's Keeper" stars Cameron Diaz ("What Happens in Vegas"), Academy Award® nominee Abigail Breslin ("Little Miss Sunshine"), Academy Award® nominee Alec Baldwin ("The Cooler," TV's "30 Rock"), Jason Patric ("In the Valley of Elah") and Academy Award® nominee Joan Cusack ("In & Out", "Working Girl"). The screenplay is by Jeremy Leven ("The Notebook") and Nick Cassavetes, based on the novel by Jodi Picoult.

The film is produced by Mark Johnson ("The Chronicles of Narnia" films), Chuck Pacheco ("Alpha Dog") and Scott L. Goldman (Lifetime's "The Tenth Circle"). Diana Pokorny, Stephen Furst, Mendel Tropper, Toby Emmerich, Merideth Finn and Mark Kaufman serve as executive producers. Hillary Sherman and Steven Posen are co-producers.

The behind-the-scenes creative team includes director of photography Caleb Deschanel ("National Treasure"), production designer Jon Hutman ("The Holiday"), Academy Award®-winning editor Alan Heim ("All That Jazz", "Alpha Dog") and editor Jim Flynn, and costume designer Shay Cunliffe ("He's Just Not That Into You"), with music by Aaron Zigman ("Sex and the City").